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Additionally, several effectively set up adverse prognostic markers, including U-CLL, ATM aberrations or NOTCH1/BIRC3 mutations, shed their adverse impact in patients taken care of with VO. The only variable that remained predictive of the shorter progression-free of charge survival In this particular cohort of people was TP53 aberrations.112 Lastly, the alternative BTK inhibitor acalabrutinib was just lately permitted by the FDA (not because of the EMA nevertheless) as frontline therapy in perspective of the outcome of the period III trial comparing acalabrutinib vs . ClbO.114
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また，強電波発信型の屋内位置測位のように複雑なアルゴ リズムを必要としないため，システムの導入が容易である．
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